The Biochemistry of Endothelial Cells

Rashmin C. Savani

Research output: Chapter in Book/Report/Conference proceedingChapter


The last two decades have seen enormous progress in vascular endothelial cell biology with significant advances in our understanding of the regulation of endothelial cell functions, the discovery and extensive study of endothelial cell relaxation and constriction factors, in particular nitric oxide, and the biology of nitric oxide synthases. Physiologic and pathophysiologic roles for endothelial cells in vascular smooth muscle cell physiology, vasodilatation, permeability, mechanosensation and mechanotransduction, leukocyte recruitment, and thrombosis have also been defined. Importantly, these mechanistic insights have led to more detailed understanding of how endothelial cells contribute to angiogenesis, lung and vascular development, tumor growth and metastasis, diabetes and insulin resistance, atherosclerosis, retinopathies, and the antiphospholipid syndrome.

Original languageEnglish (US)
Title of host publicationComparative Biology of the Normal Lung
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages12
ISBN (Electronic)9780124045774
ISBN (Print)9780124047266
StatePublished - Mar 18 2015


  • Angiogenesis
  • Atherosclerosis
  • Diabetes
  • Endothelial cells
  • Inflammation
  • Nitric oxide
  • Vascular development

ASJC Scopus subject areas

  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)


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