The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis

Vatsalya Vatsalya; Wenke Feng; Maiying Kong; Huirong Hu; Gyongyi Szabo; Arthur McCullough; Srinivasan Dasarathy; Laura E. Nagy; Svetlana Radaeva; Bruce Barton; Mack Mitchell; Craig J. McClain

doi:10.14309/ajg.0000000000002283

The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis

Vatsalya Vatsalya, Wenke Feng, Maiying Kong, Huirong Hu, Gyongyi Szabo, Arthur McCullough, Srinivasan Dasarathy, Laura E. Nagy, Svetlana Radaeva, Bruce Barton, Mack Mitchell, Craig J. McClain

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

INTRODUCTION:We investigated the effect of daily oral Lactobacillus rhamnosus GG (LGG) in reducing liver injury/severity and drinking in patients with alcohol use disorder and moderately severe alcohol-associated hepatitis.METHODS:Forty-six male and female individuals with alcohol use disorder and moderate alcohol-associated hepatitis (12 ≤ model for end-stage liver disease score < 20, aged 21-67 years) received either LGG (n = 24) or placebo (n = 22). Data were collected/assessed at baseline and at 1, 3, and 6 months.RESULTS:LGG treatment was associated with a significant reduction in liver injury after 1 month. Six months of LGG treatment reduced heavy drinking levels to social or abstinence levels.DISCUSSION:LGG treatment was associated with an improvement in both liver injury and drinking.

Original language	English (US)
Pages (from-to)	1457-1460
Number of pages	4
Journal	American Journal of Gastroenterology
Volume	118
Issue number	8
DOIs	https://doi.org/10.14309/ajg.0000000000002283
State	Published - Aug 1 2023

Keywords

alcohol intake
alcohol-associated hepatitis
lactobacillus GG
liver injury
probiotic

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.14309/ajg.0000000000002283

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Vatsalya, V., Feng, W., Kong, M., Hu, H., Szabo, G., McCullough, A., Dasarathy, S., Nagy, L. E., Radaeva, S., Barton, B., Mitchell, M., & McClain, C. J. (2023). The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis. American Journal of Gastroenterology, 118(8), 1457-1460. https://doi.org/10.14309/ajg.0000000000002283

Vatsalya, V, Feng, W, Kong, M, Hu, H, Szabo, G, McCullough, A, Dasarathy, S, Nagy, LE, Radaeva, S, Barton, B, Mitchell, M & McClain, CJ 2023, 'The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis', American Journal of Gastroenterology, vol. 118, no. 8, pp. 1457-1460. https://doi.org/10.14309/ajg.0000000000002283

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abstract = "INTRODUCTION:We investigated the effect of daily oral Lactobacillus rhamnosus GG (LGG) in reducing liver injury/severity and drinking in patients with alcohol use disorder and moderately severe alcohol-associated hepatitis.METHODS:Forty-six male and female individuals with alcohol use disorder and moderate alcohol-associated hepatitis (12 ≤ model for end-stage liver disease score < 20, aged 21-67 years) received either LGG (n = 24) or placebo (n = 22). Data were collected/assessed at baseline and at 1, 3, and 6 months.RESULTS:LGG treatment was associated with a significant reduction in liver injury after 1 month. Six months of LGG treatment reduced heavy drinking levels to social or abstinence levels.DISCUSSION:LGG treatment was associated with an improvement in both liver injury and drinking.",

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author = "Vatsalya Vatsalya and Wenke Feng and Maiying Kong and Huirong Hu and Gyongyi Szabo and Arthur McCullough and Srinivasan Dasarathy and Nagy, {Laura E.} and Svetlana Radaeva and Bruce Barton and Mack Mitchell and McClain, {Craig J.}",

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AU - Hu, Huirong

AU - Szabo, Gyongyi

AU - McCullough, Arthur

AU - Dasarathy, Srinivasan

AU - Nagy, Laura E.

AU - Radaeva, Svetlana

AU - Barton, Bruce

AU - Mitchell, Mack

AU - McClain, Craig J.

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AB - INTRODUCTION:We investigated the effect of daily oral Lactobacillus rhamnosus GG (LGG) in reducing liver injury/severity and drinking in patients with alcohol use disorder and moderately severe alcohol-associated hepatitis.METHODS:Forty-six male and female individuals with alcohol use disorder and moderate alcohol-associated hepatitis (12 ≤ model for end-stage liver disease score < 20, aged 21-67 years) received either LGG (n = 24) or placebo (n = 22). Data were collected/assessed at baseline and at 1, 3, and 6 months.RESULTS:LGG treatment was associated with a significant reduction in liver injury after 1 month. Six months of LGG treatment reduced heavy drinking levels to social or abstinence levels.DISCUSSION:LGG treatment was associated with an improvement in both liver injury and drinking.

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KW - probiotic

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The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis

Abstract

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