Abstract
In conclusion, Argonaute proteins comprise a highly conserved protein family that is involved in a variety of RNA silencing phenomena in a diverse set of organisms. Perhaps through RNAi-related pathways or possibly also through distinct mechanisms, Argonaute family members have a variety of biological roles. These include regulation of development and determination of stem-cell character. Through an ever-advancing understanding of the biochemistry and genetics of the Argonaute family, we may ultimately reveal the reach of these pathways into the basic biological mechanisms that underlie a variety of human diseases.
Original language | English (US) |
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Pages (from-to) | 2733-2742 |
Number of pages | 10 |
Journal | Genes and Development |
Volume | 16 |
Issue number | 21 |
DOIs | |
State | Published - Nov 1 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Developmental Biology