Abstract
We have characterized a precursor protein which gives rise to the neuropeptide Phe-Met-Arg-Phe-amide (FMRFamide) by determining the nucleotide sequence of a genomic and five cDNA clones. The 597-aminoacid protein contains 28 copies of the tetrapeptide FMRFamide, a single Phe-Leu-Arg-Phe-amide (FLRFamide), and other sequences flanked by paired basic residues, some of which have homologies to mammalian brain peptides. The data presented suggest the genes encoding pro-opiomelanocortin, pre-pro-enkephalin, and the hypothalamic releasing factor, cortico-releasing factor (CRF), arose from a common ancestral gene.
Original language | English (US) |
---|---|
Pages (from-to) | 453-461 |
Number of pages | 9 |
Journal | DNA |
Volume | 5 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1986 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics