TY - JOUR
T1 - The Aplysia FMRFamide Gene Encodes Sequences Related to Mammalian Brain Peptides
AU - Taussig, R.
AU - Scheller, R. H.
PY - 1986/12
Y1 - 1986/12
N2 - We have characterized a precursor protein which gives rise to the neuropeptide Phe-Met-Arg-Phe-amide (FMRFamide) by determining the nucleotide sequence of a genomic and five cDNA clones. The 597-aminoacid protein contains 28 copies of the tetrapeptide FMRFamide, a single Phe-Leu-Arg-Phe-amide (FLRFamide), and other sequences flanked by paired basic residues, some of which have homologies to mammalian brain peptides. The data presented suggest the genes encoding pro-opiomelanocortin, pre-pro-enkephalin, and the hypothalamic releasing factor, cortico-releasing factor (CRF), arose from a common ancestral gene.
AB - We have characterized a precursor protein which gives rise to the neuropeptide Phe-Met-Arg-Phe-amide (FMRFamide) by determining the nucleotide sequence of a genomic and five cDNA clones. The 597-aminoacid protein contains 28 copies of the tetrapeptide FMRFamide, a single Phe-Leu-Arg-Phe-amide (FLRFamide), and other sequences flanked by paired basic residues, some of which have homologies to mammalian brain peptides. The data presented suggest the genes encoding pro-opiomelanocortin, pre-pro-enkephalin, and the hypothalamic releasing factor, cortico-releasing factor (CRF), arose from a common ancestral gene.
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U2 - 10.1089/dna.1.1986.5.453
DO - 10.1089/dna.1.1986.5.453
M3 - Article
C2 - 3816495
AN - SCOPUS:0022845758
SN - 1044-5498
VL - 5
SP - 453
EP - 461
JO - DNA and Cell Biology
JF - DNA and Cell Biology
IS - 6
ER -