TY - JOUR
T1 - The anatomy and immunology of vasculature in the central nervous system
AU - Mastorakos, Panagiotis
AU - McGavern, Dorian
N1 - Funding Information:
Acknowledgments: We thank A. Hoofring in the NIH Medical Arts Design Section for help with all the illustrations. Funding: This work was supported by the intramural program at the National Institute of Neurological Disorders and Stroke (NINDS), NIH.
Publisher Copyright:
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
PY - 2019/7/12
Y1 - 2019/7/12
N2 - Barriers between circulation and the central nervous system (CNS) play a key role in the development and modulation of CNS immune responses. Structural variations in the vasculature traversing different anatomical regions within the CNS strongly influence where and how CNS immune responses first develop. Here, we provide an overview of cerebrovascular anatomy, focusing on the blood-CNS interface and how anatomical variations influence steady-state immunology in the compartment. We then discuss how CNS vasculature is affected by and influences the development of different pathophysiological states, such as CNS autoimmune disease, cerebrovascular injury, cerebral ischemia, and infection.
AB - Barriers between circulation and the central nervous system (CNS) play a key role in the development and modulation of CNS immune responses. Structural variations in the vasculature traversing different anatomical regions within the CNS strongly influence where and how CNS immune responses first develop. Here, we provide an overview of cerebrovascular anatomy, focusing on the blood-CNS interface and how anatomical variations influence steady-state immunology in the compartment. We then discuss how CNS vasculature is affected by and influences the development of different pathophysiological states, such as CNS autoimmune disease, cerebrovascular injury, cerebral ischemia, and infection.
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U2 - 10.1126/sciimmunol.aav0492
DO - 10.1126/sciimmunol.aav0492
M3 - Review article
C2 - 31300479
AN - SCOPUS:85069646055
SN - 2470-9468
VL - 4
JO - Science Immunology
JF - Science Immunology
IS - 37
M1 - eaav0492
ER -