The acute and transient nature of idiopathic immune hemolytic anemia in childhood

George R. Buchanan, Laurence A. Boxer, David G. Nathan

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


The records of 22 children with the diagnosis of idiopathic immune hemolytic anemia were reviewed. Fifty per cent of the children had a history of an antecedent infection and 32% had underlying immune deficiency or lymphoproliferative diseases. The majority (77%) of the patients had an acute self-limited disease which was frequently associated with a positive complement or nongamma Coombs test. The anemia was usually severe, and a number of the children had reticulocytopenia at the time of diagnosis. These children responded rapidly to transfusions and corticosteroids and generally remained well on follow-up. Immnosuppressive drugs did not prove useful in two patients refractory to prednisone, but splenectomy was apparently beneficial in three of four patients so treated. Mortality rate was 18%, with most of the deaths related to an underlying disease.

Original languageEnglish (US)
Pages (from-to)780-783
Number of pages4
JournalThe Journal of pediatrics
Issue number5
StatePublished - May 1976

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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