TY - JOUR
T1 - The absence of unique kainic acid-like molecules in urine, serum, and CSF from Huntington's disease patients
AU - Beutler, Bruce A.
AU - Noronha, Avertano B C
AU - Poon, Michele M.
AU - Arnason, Barry G W
N1 - Funding Information:
Supported by grants from the National Huntington's Disease Association, the Hereditary Disease Foundation and the Nancy Pritzker Fund. Reprint requests to: Avertano B.C. Noronha, M.D., Department of Neurology, The University of Chicago, 950 E. 59th Street, Chicago, IL 60637, U.S.A.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1981/9
Y1 - 1981/9
N2 - By means of a sensitive competition assay, serum, urine, and CSF from patients with Huntington's disease (HD) and controls were tested for the presence of molecules capable of displacing radioactive kainic acid (KA) from rat brain receptors. No difference was found between HD and control samples. It is unlikely that systemic production of an endogenous toxin structurally related to KA occurs in HD.
AB - By means of a sensitive competition assay, serum, urine, and CSF from patients with Huntington's disease (HD) and controls were tested for the presence of molecules capable of displacing radioactive kainic acid (KA) from rat brain receptors. No difference was found between HD and control samples. It is unlikely that systemic production of an endogenous toxin structurally related to KA occurs in HD.
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U2 - 10.1016/0022-510X(81)90113-1
DO - 10.1016/0022-510X(81)90113-1
M3 - Article
C2 - 6115893
AN - SCOPUS:0019417835
SN - 0022-510X
VL - 51
SP - 355
EP - 360
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 3
ER -