Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes

Zibo Li; Hancheng Cai; Matthew Hassink; Melissa L. Blackman; Richard C D Brown; Peter S. Conti; Joseph M. Fox

doi:10.1039/c0cc03078c

Tetrazine-trans-cyclooctene ligation for the rapid construction of ¹⁸F labeled probes

Zibo Li, Hancheng Cai, Matthew Hassink, Melissa L. Blackman, Richard C D Brown, Peter S. Conti, Joseph M. Fox

Research output: Contribution to journal › Article › peer-review

157 Scopus citations

Abstract

A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an ¹⁸F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

Original language	English (US)
Pages (from-to)	8043-8045
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	42
DOIs	https://doi.org/10.1039/c0cc03078c
State	Published - Nov 14 2010

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes",

abstract = "A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an 18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.",

author = "Zibo Li and Hancheng Cai and Matthew Hassink and Blackman, {Melissa L.} and Brown, {Richard C D} and Conti, {Peter S.} and Fox, {Joseph M.}",

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T1 - Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes

AU - Li, Zibo

AU - Cai, Hancheng

AU - Hassink, Matthew

AU - Blackman, Melissa L.

AU - Brown, Richard C D

AU - Conti, Peter S.

AU - Fox, Joseph M.

PY - 2010/11/14

Y1 - 2010/11/14

N2 - A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an 18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

AB - A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an 18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

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M3 - Article

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JO - Chemical Communications

JF - Chemical Communications

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Tetrazine-trans-cyclooctene ligation for the rapid construction of ¹⁸F labeled probes

Abstract

ASJC Scopus subject areas

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