Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes

Zibo Li, Hancheng Cai, Matthew Hassink, Melissa L. Blackman, Richard C D Brown, Peter S. Conti, Joseph M. Fox

Research output: Contribution to journalArticlepeer-review

151 Scopus citations


A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an 18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

Original languageEnglish (US)
Pages (from-to)8043-8045
Number of pages3
JournalChemical Communications
Issue number42
StatePublished - Nov 14 2010

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


Dive into the research topics of 'Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes'. Together they form a unique fingerprint.

Cite this