Telomere positional effects and the regulation of cellular senescence

Woodring E. Wright, Jerry W. Shay

Research output: Contribution to journalArticlepeer-review

245 Scopus citations


Normal cells have a limited capacity to proliferate but the molecular clock that regulates the onset of cellular senescence remains unidentified. The ends of chromosomes-telomeres - have been shown to shorten progressively with age in normal cells. Here, were present a working model of how telomeric shortening may induce programmed changes in the regulation of cellular proliferation.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalTrends in Genetics
Issue number6
StatePublished - Jun 1992

ASJC Scopus subject areas

  • Genetics


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