Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology

Woodring E. Wright; Jerry W. Shay

doi:10.1038/78592

Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology

Woodring E. Wright, Jerry W. Shay

Research output: Contribution to journal › Review article › peer-review

339 Scopus citations

Abstract

Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer.

Original language	English (US)
Pages (from-to)	849-851
Number of pages	3
Journal	Nature medicine
Volume	6
Issue number	8
DOIs	https://doi.org/10.1038/78592
State	Published - Aug 2000

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology",

abstract = "Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer.",

author = "Wright, {Woodring E.} and Shay, {Jerry W.}",

year = "2000",

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AU - Shay, Jerry W.

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Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology

Abstract

ASJC Scopus subject areas

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