Telomerase activity in human brain tumours

L. A. Langford; M. A. Piatyszek; J. W. Shay; S. Clifford Schold

doi:10.1016/S0140-6736(95)91865-5

Telomerase activity in human brain tumours

L. A. Langford, M. A. Piatyszek, J. W. Shay, S. Clifford Schold

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227 Scopus citations

Abstract

Malignant gliomas are invasive into surrounding brain and are refractory to therapy. Telomerase stabilises telomere length and may immortalise cells to allow unlimited proliferation. Our analysis of telomerase activity in 90 human gliomas showed that 19 of 19 oligodendrogliomas and 38 of 51 glioblastoma multiformes have detectable telomerase activity. The absence of telomerase activity in anaplastic astrocytomas (2/20 positive) and in one-quarter (13/51) of the glioblastomas suggests that these tumours follow different pathways of neoplastic progression. Thus we have found that a distinct subgroup of brain tumour consists of transformed yet pre-immortal cells.

Original language	English (US)
Pages (from-to)	1267-1268
Number of pages	2
Journal	The Lancet
Volume	346
Issue number	8985
DOIs	https://doi.org/10.1016/S0140-6736(95)91865-5
State	Published - Nov 11 1995

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(95)91865-5

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title = "Telomerase activity in human brain tumours",

abstract = "Malignant gliomas are invasive into surrounding brain and are refractory to therapy. Telomerase stabilises telomere length and may immortalise cells to allow unlimited proliferation. Our analysis of telomerase activity in 90 human gliomas showed that 19 of 19 oligodendrogliomas and 38 of 51 glioblastoma multiformes have detectable telomerase activity. The absence of telomerase activity in anaplastic astrocytomas (2/20 positive) and in one-quarter (13/51) of the glioblastomas suggests that these tumours follow different pathways of neoplastic progression. Thus we have found that a distinct subgroup of brain tumour consists of transformed yet pre-immortal cells.",

author = "Langford, {L. A.} and Piatyszek, {M. A.} and Shay, {J. W.} and Schold, {S. Clifford}",

note = "Funding Information: This work was supported by a research grant from the University of Texas M D Anderson Cancer Center Patient Referral Service (LAL) and the Geron Corporation, Menlo Park, California (MAP, JWS).",

year = "1995",

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T1 - Telomerase activity in human brain tumours

AU - Langford, L. A.

AU - Piatyszek, M. A.

AU - Shay, J. W.

AU - Schold, S. Clifford

N1 - Funding Information: This work was supported by a research grant from the University of Texas M D Anderson Cancer Center Patient Referral Service (LAL) and the Geron Corporation, Menlo Park, California (MAP, JWS).

PY - 1995/11/11

Y1 - 1995/11/11

N2 - Malignant gliomas are invasive into surrounding brain and are refractory to therapy. Telomerase stabilises telomere length and may immortalise cells to allow unlimited proliferation. Our analysis of telomerase activity in 90 human gliomas showed that 19 of 19 oligodendrogliomas and 38 of 51 glioblastoma multiformes have detectable telomerase activity. The absence of telomerase activity in anaplastic astrocytomas (2/20 positive) and in one-quarter (13/51) of the glioblastomas suggests that these tumours follow different pathways of neoplastic progression. Thus we have found that a distinct subgroup of brain tumour consists of transformed yet pre-immortal cells.

AB - Malignant gliomas are invasive into surrounding brain and are refractory to therapy. Telomerase stabilises telomere length and may immortalise cells to allow unlimited proliferation. Our analysis of telomerase activity in 90 human gliomas showed that 19 of 19 oligodendrogliomas and 38 of 51 glioblastoma multiformes have detectable telomerase activity. The absence of telomerase activity in anaplastic astrocytomas (2/20 positive) and in one-quarter (13/51) of the glioblastomas suggests that these tumours follow different pathways of neoplastic progression. Thus we have found that a distinct subgroup of brain tumour consists of transformed yet pre-immortal cells.

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JO - The Lancet

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Telomerase activity in human brain tumours

Abstract

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