TY - JOUR
T1 - T–cell Acute Lymphoblastic Leukemia in a Patient with Pre–existing Essential Thrombocythemia
T2 - A Case Report and Literature Review
AU - Medawar, Georgio
AU - Ackula, Haritha
AU - Weinberg, Olga
AU - Roberts, Todd
AU - Meleveedu, Kapil
N1 - Publisher Copyright:
© 2021
PY - 2021/1
Y1 - 2021/1
N2 - The occurrence of T–cell acute lymphoblastic leukemia (T–ALL), on a background of preexisting Philadelphia–negative Myeloproliferative neoplasm is rare. Among the few reported cases where no deep molecular sequencing was performed, it was difficult to ascertain whether these leukemia's occurred de-novo or were due to the clonal progression of underlying MPN. We present a case of a 49–year-old man with a history of essential thrombocythemia who subsequently developed T–ALL. By utilizing next generation sequencing we were able to determine that these two entities originated from two distinct clones and were likely random events. We report the outcome and review the literature.
AB - The occurrence of T–cell acute lymphoblastic leukemia (T–ALL), on a background of preexisting Philadelphia–negative Myeloproliferative neoplasm is rare. Among the few reported cases where no deep molecular sequencing was performed, it was difficult to ascertain whether these leukemia's occurred de-novo or were due to the clonal progression of underlying MPN. We present a case of a 49–year-old man with a history of essential thrombocythemia who subsequently developed T–ALL. By utilizing next generation sequencing we were able to determine that these two entities originated from two distinct clones and were likely random events. We report the outcome and review the literature.
KW - Essential thrombocythemia
KW - Myeloproliferative disorders
KW - Next generation sequencing
KW - T–cell acute lymphoblastic leukemia
UR - http://www.scopus.com/inward/record.url?scp=85112246120&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85112246120&partnerID=8YFLogxK
U2 - 10.1016/j.lrr.2021.100264
DO - 10.1016/j.lrr.2021.100264
M3 - Article
C2 - 34430196
AN - SCOPUS:85112246120
SN - 2213-0489
VL - 16
JO - Leukemia Research Reports
JF - Leukemia Research Reports
M1 - 100264
ER -