Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation

Frederick J. Bonte, Thomas S. Harris, Linda S. Hynan, Eileen H. Bigio, Charles L. White

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


PURPOSE: The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias, with particular reference to Alzheimer disease. MATERIALS AND METHODS: Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 49 subjects were ultimately compared with neuropathologic study of the brain at autopsy. RESULTS: Sensitivity = 86.7% (68.4-95.6%, 95% confidence interval [CI]), specificity = 89.5% (65.5-98.2% CI), positive predictive value = 92.9% (75.0-98.8% CI), negative predictive value = 81% (57.4-93.7% CI), accuracy = 87.8% (74.5-94.9% CI), likelihood ratio = 8.23% (7.09-9.57% CI). CONCLUSIONS: Comparison is made with several other SPECT and PET series with histopathologic correlation. Brain blood flow SPECT is useful in the diagnosis and differential diagnosis of the dementias.

Original languageEnglish (US)
Pages (from-to)376-378
Number of pages3
JournalClinical nuclear medicine
Issue number7
StatePublished - Jul 2006


  • Brain SPECT with histopathologic correlation
  • SPECT in Alzheimer disease
  • SPECT in frontotemporal dementias
  • SPECT in the dementias

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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