TB or not TB: How Mycobacterium tuberculosis may evade drug treatment

Errol C. Friedberg; Paula L. Fischhaber

doi:10.1016/S0092-8674(03)00275-7

TB or not TB: How Mycobacterium tuberculosis may evade drug treatment

Errol C. Friedberg, Paula L. Fischhaber

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

In this issue of Cell, a study by Valerie Mizrahi and her colleagues (Boshoff et al., 2003) suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of M. tuberculosis.

Original language	English (US)
Pages (from-to)	139-140
Number of pages	2
Journal	Cell
Volume	113
Issue number	2
DOIs	https://doi.org/10.1016/S0092-8674(03)00275-7
State	Published - Apr 18 2003

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/S0092-8674(03)00275-7

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abstract = "In this issue of Cell, a study by Valerie Mizrahi and her colleagues (Boshoff et al., 2003) suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of M. tuberculosis.",

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AB - In this issue of Cell, a study by Valerie Mizrahi and her colleagues (Boshoff et al., 2003) suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of M. tuberculosis.

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TB or not TB: How Mycobacterium tuberculosis may evade drug treatment

Abstract

ASJC Scopus subject areas

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