Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model

Chiatogu Onyewu; Emily Eads; Wiley A. Schell; John R. Perfect; Yehuda Ullmann; Gil Kaufman; Benjamin A. Horwitz; Israela Berdicevsky; Joseph Heitman

doi:10.1128/AAC.00492-07

Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model

Chiatogu Onyewu, Emily Eads, Wiley A. Schell, John R. Perfect, Yehuda Ullmann, Gil Kaufman, Benjamin A. Horwitz, Israela Berdicevsky, Joseph Heitman

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Fluconazole-FK506 or fluconazole-cyclosporine drug combinations were tested in an ex vivo Trichophyton mentagrophytes human skin infection model. Conidia colonization was monitored by scanning electron microscopy over a 7-day treatment period. The fluconazole-FK506 combination demonstrated the most obvious advantage over single-drug therapy by clearing conidia and protecting skin from damage at low drug concentrations.

Original language	English (US)
Pages (from-to)	3743-3746
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	51
Issue number	10
DOIs	https://doi.org/10.1128/AAC.00492-07
State	Published - Oct 2007

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Onyewu, C., Eads, E., Schell, W. A., Perfect, J. R., Ullmann, Y., Kaufman, G., Horwitz, B. A., Berdicevsky, I., & Heitman, J. (2007). Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. Antimicrobial agents and chemotherapy, 51(10), 3743-3746. https://doi.org/10.1128/AAC.00492-07

Onyewu, C, Eads, E, Schell, WA, Perfect, JR, Ullmann, Y, Kaufman, G, Horwitz, BA, Berdicevsky, I & Heitman, J 2007, 'Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model', Antimicrobial agents and chemotherapy, vol. 51, no. 10, pp. 3743-3746. https://doi.org/10.1128/AAC.00492-07

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AU - Kaufman, Gil

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Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model

Abstract

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