Tango between Ubiquitin Ligase and Deubiquitinase Keeps Cyclin A Tag Free

Hongtao Yu

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations

Abstract

Ubiquitin ligases (E3s) and ubiquitin-specific proteases (USPs) dynamically oppose each other during ubiquitination. In this issue of Molecular Cell, Huang et al. (2011) provide a counterintuitive example of a USP residing in an E3 complex, and establish Usp37 as a gatekeeper of APC/C-mediated ubiquitination of cyclin A.

Original languageEnglish (US)
Pages (from-to)409-410
Number of pages2
JournalMolecular cell
Volume42
Issue number4
DOIs
StatePublished - May 20 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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