TY - JOUR
T1 - T cell-derived b cell differentiation factor(s) effect on the isotype switch of murine b cells
AU - Isakson, Peter C.
AU - Pure, Ellen
AU - Vitetta, Ellen S.
AU - Krammer, Peter H.
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Small IgM+, IgD+ B cells can switch to the production of other classes (and subclasses) of immunoglobulin (Ig) (1-4). This switch can be induced by either antigenic (5, 6) or mitogenic stimulation (7). The nature of the antigen (8), the site of antigen injection (9), and the nature of the T cell response (8, 10-13) can determine the class of Ig produced in vivo. In particular, the switch in isotype synthesis isrelatively T cell dependent (8, 10, 11). Furthermore, T cells can influence the subclassg- of IgG secreted by B cells (12, 13). However, in low density cell cultures in thett presence of lipopolysaccharide (LPS),1 IgG secretion by murine B cells may not3 require T cells (5, 14-17).
AB - Small IgM+, IgD+ B cells can switch to the production of other classes (and subclasses) of immunoglobulin (Ig) (1-4). This switch can be induced by either antigenic (5, 6) or mitogenic stimulation (7). The nature of the antigen (8), the site of antigen injection (9), and the nature of the T cell response (8, 10-13) can determine the class of Ig produced in vivo. In particular, the switch in isotype synthesis isrelatively T cell dependent (8, 10, 11). Furthermore, T cells can influence the subclassg- of IgG secreted by B cells (12, 13). However, in low density cell cultures in thett presence of lipopolysaccharide (LPS),1 IgG secretion by murine B cells may not3 require T cells (5, 14-17).
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M3 - Article
C2 - 23335801
AN - SCOPUS:84872718269
SN - 0022-1767
VL - 190
SP - 849
EP - 863
JO - Journal of Immunology
JF - Journal of Immunology
IS - 3
ER -