Synthetic Hybrid-Scale Fiber Matrix in the Trauma and Acute Care Surgical Practice

Luis Fernandez, Adam Shar, Marc Matthews, Paul J. Kim, Christopher Thompson, Natalie Williams, Mandy Stutsman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Complex cutaneous wounds resulting from disease and trauma can be difficult to heal and may require advanced treatment options. Split-thickness skin grafts (STSGs) and other biologic allogeneic and xenogeneic skin substitutes are limited in their ability to manage these lesions, and STSGs may also be limited in availability. A synthetic hybrid-scale fiber matrix, engineered with an architecture similar to native extracellular matrix, has been shown to have excellent durability and does not carry the risks of disease transmission or inflammatory response associated with biologic materials; it may offer a new option for managing these complex wounds. In this preliminary study, the synthetic matrix was used to treat 3 patients with difficult-to-treat wounds, including lesions associated with calciphylaxis, enteroatmospheric abdominal fistula, and necrotizing fasciitis of the hand with exposed tendon. Treatment with the synthetic matrix resulted in significant reepithelialization and wound healing. The successful results suggest that the synthetic matrix enables healing of complex cutaneous wounds and may be a reasonable alternative to STSG, even in particularly challenging cases.

Original languageEnglish (US)
Pages (from-to)237-244
Number of pages8
Issue number9
StatePublished - Sep 2021


  • acute wound P
  • negative pressure wound therapy
  • split-thickness skin graft
  • synthetic hybrid-scale fiber matrix

ASJC Scopus subject areas

  • Medicine(all)


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