TY - JOUR
T1 - Synthetic Hybrid-Scale Fiber Matrix in the Trauma and Acute Care Surgical Practice
AU - Fernandez, Luis
AU - Shar, Adam
AU - Matthews, Marc
AU - Kim, Paul J.
AU - Thompson, Christopher
AU - Williams, Natalie
AU - Stutsman, Mandy
N1 - Publisher Copyright:
© 2021 HMP Communications. All rights reserved.
PY - 2021/9
Y1 - 2021/9
N2 - Complex cutaneous wounds resulting from disease and trauma can be difficult to heal and may require advanced treatment options. Split-thickness skin grafts (STSGs) and other biologic allogeneic and xenogeneic skin substitutes are limited in their ability to manage these lesions, and STSGs may also be limited in availability. A synthetic hybrid-scale fiber matrix, engineered with an architecture similar to native extracellular matrix, has been shown to have excellent durability and does not carry the risks of disease transmission or inflammatory response associated with biologic materials; it may offer a new option for managing these complex wounds. In this preliminary study, the synthetic matrix was used to treat 3 patients with difficult-to-treat wounds, including lesions associated with calciphylaxis, enteroatmospheric abdominal fistula, and necrotizing fasciitis of the hand with exposed tendon. Treatment with the synthetic matrix resulted in significant reepithelialization and wound healing. The successful results suggest that the synthetic matrix enables healing of complex cutaneous wounds and may be a reasonable alternative to STSG, even in particularly challenging cases.
AB - Complex cutaneous wounds resulting from disease and trauma can be difficult to heal and may require advanced treatment options. Split-thickness skin grafts (STSGs) and other biologic allogeneic and xenogeneic skin substitutes are limited in their ability to manage these lesions, and STSGs may also be limited in availability. A synthetic hybrid-scale fiber matrix, engineered with an architecture similar to native extracellular matrix, has been shown to have excellent durability and does not carry the risks of disease transmission or inflammatory response associated with biologic materials; it may offer a new option for managing these complex wounds. In this preliminary study, the synthetic matrix was used to treat 3 patients with difficult-to-treat wounds, including lesions associated with calciphylaxis, enteroatmospheric abdominal fistula, and necrotizing fasciitis of the hand with exposed tendon. Treatment with the synthetic matrix resulted in significant reepithelialization and wound healing. The successful results suggest that the synthetic matrix enables healing of complex cutaneous wounds and may be a reasonable alternative to STSG, even in particularly challenging cases.
KW - acute wound P
KW - negative pressure wound therapy
KW - split-thickness skin graft
KW - synthetic hybrid-scale fiber matrix
UR - http://www.scopus.com/inward/record.url?scp=85121620698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85121620698&partnerID=8YFLogxK
U2 - 10.25270/wnds/2021.237244
DO - 10.25270/wnds/2021.237244
M3 - Article
C2 - 34734842
AN - SCOPUS:85121620698
SN - 1044-7946
VL - 33
SP - 237
EP - 244
JO - Wounds
JF - Wounds
IS - 9
ER -