Synthesis of Thromboresistant Heparinized Polysilicone Using Radiation Grafting

J. E. Wilson; R. C. Eberhart; A. B. Elkowitz

doi:10.1080/00222338108056824

Synthesis of Thromboresistant Heparinized Polysilicone Using Radiation Grafting

J. E. Wilson, R. C. Eberhart, A. B. Elkowitz

Surgery

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Abstract

Gamma rays from 60Co were used to graft chloromethylstyrene on samples of polysilicone, followed by quaternization with pyridine, then reaction with sodium heparin to replace chloride ions in the samples with heparin anions. Extraction tests on the heparinized samples with normal saline solution showed a maximum heparin removal rate of 5 x 10-8 g/cm2/min. The heparinized polysilicone was found to be more blood compatible than untreated polysilicone in a rabbit ex vivo bleeding test.

Original language	English (US)
Pages (from-to)	769-782
Number of pages	14
Journal	Journal of Macromolecular Science: Part A - Chemistry
Volume	16
Issue number	4
DOIs	https://doi.org/10.1080/00222338108056824
State	Published - Jan 1981

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10.1080/00222338108056824

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title = "Synthesis of Thromboresistant Heparinized Polysilicone Using Radiation Grafting",

abstract = "Gamma rays from 60Co were used to graft chloromethylstyrene on samples of polysilicone, followed by quaternization with pyridine, then reaction with sodium heparin to replace chloride ions in the samples with heparin anions. Extraction tests on the heparinized samples with normal saline solution showed a maximum heparin removal rate of 5 x 10-8 g/cm2/min. The heparinized polysilicone was found to be more blood compatible than untreated polysilicone in a rabbit ex vivo bleeding test.",

author = "Wilson, {J. E.} and Eberhart, {R. C.} and Elkowitz, {A. B.}",

note = "Funding Information: The authors would like to acknowledge the support of this research by grants from the National Institutes of Health (R01-HL-2-1994) and the Petroleum Research Fund of the American Chemical Society (9794-B1, 6). The student research assistants were Ms Tecora Jones and Mr Ralph Barnet.",

year = "1981",

month = jan,

doi = "10.1080/00222338108056824",

language = "English (US)",

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T1 - Synthesis of Thromboresistant Heparinized Polysilicone Using Radiation Grafting

AU - Wilson, J. E.

AU - Eberhart, R. C.

AU - Elkowitz, A. B.

N1 - Funding Information: The authors would like to acknowledge the support of this research by grants from the National Institutes of Health (R01-HL-2-1994) and the Petroleum Research Fund of the American Chemical Society (9794-B1, 6). The student research assistants were Ms Tecora Jones and Mr Ralph Barnet.

PY - 1981/1

Y1 - 1981/1

N2 - Gamma rays from 60Co were used to graft chloromethylstyrene on samples of polysilicone, followed by quaternization with pyridine, then reaction with sodium heparin to replace chloride ions in the samples with heparin anions. Extraction tests on the heparinized samples with normal saline solution showed a maximum heparin removal rate of 5 x 10-8 g/cm2/min. The heparinized polysilicone was found to be more blood compatible than untreated polysilicone in a rabbit ex vivo bleeding test.

AB - Gamma rays from 60Co were used to graft chloromethylstyrene on samples of polysilicone, followed by quaternization with pyridine, then reaction with sodium heparin to replace chloride ions in the samples with heparin anions. Extraction tests on the heparinized samples with normal saline solution showed a maximum heparin removal rate of 5 x 10-8 g/cm2/min. The heparinized polysilicone was found to be more blood compatible than untreated polysilicone in a rabbit ex vivo bleeding test.

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Synthesis of Thromboresistant Heparinized Polysilicone Using Radiation Grafting

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