Synthesis and PET imaging studies of [18F]2-fluoroquinolin-8-ol ([18F]CABS13) in transgenic mouse models of Alzheimer's disease

Neil Vasdev; Pengpeng Cao; Erik M. Van Oosten; Alan A. Wilson; Sylvain Houle; Guiyang Hao; Xiankai Sun; Nikolai Slavine; Mustafa Alhasan; Peter P. Antich; Frederick J. Bonte; Padmakar Kulkarni

doi:10.1039/c2md20075a

Synthesis and PET imaging studies of [¹⁸F]2-fluoroquinolin-8-ol ([¹⁸F]CABS13) in transgenic mouse models of Alzheimer's disease

Neil Vasdev, Pengpeng Cao, Erik M. Van Oosten, Alan A. Wilson, Sylvain Houle, Guiyang Hao, Xiankai Sun, Nikolai Slavine, Mustafa Alhasan, Peter P. Antich, Frederick J. Bonte, Padmakar Kulkarni

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Benzyloxy-2-chloroquinoline was reacted with fluorine-18 labelled potassium cryptand fluoride, followed by catalytic hydrogenation to prepare [ ¹⁸F]2-fluoroquinolin-8-ol in high radiochemical yields (30%; uncorrected and relative to [¹⁸F]-fluoride), specific activities (>1 Ci μmol^-1) and radiochemical purities (>99%) within 70 min; PET-CT imaging with this new radiotracer in double transgenic mice shows excellent promise for imaging Alzheimer's disease.

Original language	English (US)
Pages (from-to)	1228-1230
Number of pages	3
Journal	MedChemComm
Volume	3
Issue number	10
DOIs	https://doi.org/10.1039/c2md20075a
State	Published - Oct 2012

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

Access to Document

10.1039/c2md20075a

Cite this

@article{51f96939ec89402ab0bdb69839fcd74a,

title = "Synthesis and PET imaging studies of [18F]2-fluoroquinolin-8-ol ([18F]CABS13) in transgenic mouse models of Alzheimer's disease",

abstract = "Benzyloxy-2-chloroquinoline was reacted with fluorine-18 labelled potassium cryptand fluoride, followed by catalytic hydrogenation to prepare [ 18F]2-fluoroquinolin-8-ol in high radiochemical yields (30%; uncorrected and relative to [18F]-fluoride), specific activities (>1 Ci μmol-1) and radiochemical purities (>99%) within 70 min; PET-CT imaging with this new radiotracer in double transgenic mice shows excellent promise for imaging Alzheimer's disease.",

author = "Neil Vasdev and Pengpeng Cao and {Van Oosten}, {Erik M.} and Wilson, {Alan A.} and Sylvain Houle and Guiyang Hao and Xiankai Sun and Nikolai Slavine and Mustafa Alhasan and Antich, {Peter P.} and Bonte, {Frederick J.} and Padmakar Kulkarni",

year = "2012",

month = oct,

doi = "10.1039/c2md20075a",

language = "English (US)",

volume = "3",

pages = "1228--1230",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "10",

}

TY - JOUR

T1 - Synthesis and PET imaging studies of [18F]2-fluoroquinolin-8-ol ([18F]CABS13) in transgenic mouse models of Alzheimer's disease

AU - Vasdev, Neil

AU - Cao, Pengpeng

AU - Van Oosten, Erik M.

AU - Wilson, Alan A.

AU - Houle, Sylvain

AU - Hao, Guiyang

AU - Sun, Xiankai

AU - Slavine, Nikolai

AU - Alhasan, Mustafa

AU - Antich, Peter P.

AU - Bonte, Frederick J.

AU - Kulkarni, Padmakar

PY - 2012/10

Y1 - 2012/10

N2 - Benzyloxy-2-chloroquinoline was reacted with fluorine-18 labelled potassium cryptand fluoride, followed by catalytic hydrogenation to prepare [ 18F]2-fluoroquinolin-8-ol in high radiochemical yields (30%; uncorrected and relative to [18F]-fluoride), specific activities (>1 Ci μmol-1) and radiochemical purities (>99%) within 70 min; PET-CT imaging with this new radiotracer in double transgenic mice shows excellent promise for imaging Alzheimer's disease.

AB - Benzyloxy-2-chloroquinoline was reacted with fluorine-18 labelled potassium cryptand fluoride, followed by catalytic hydrogenation to prepare [ 18F]2-fluoroquinolin-8-ol in high radiochemical yields (30%; uncorrected and relative to [18F]-fluoride), specific activities (>1 Ci μmol-1) and radiochemical purities (>99%) within 70 min; PET-CT imaging with this new radiotracer in double transgenic mice shows excellent promise for imaging Alzheimer's disease.

UR - http://www.scopus.com/inward/record.url?scp=84866981272&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866981272&partnerID=8YFLogxK

U2 - 10.1039/c2md20075a

DO - 10.1039/c2md20075a

M3 - Article

AN - SCOPUS:84866981272

SN - 2040-2503

VL - 3

SP - 1228

EP - 1230

JO - MedChemComm

JF - MedChemComm

IS - 10

ER -

Synthesis and PET imaging studies of [¹⁸F]2-fluoroquinolin-8-ol ([¹⁸F]CABS13) in transgenic mouse models of Alzheimer's disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this