Synthesis and biodegradation of nanogels as delivery carriers for carbohydrate drugs

Jung Kwon Oh; Daniel J. Siegwart; Krzysztof Matyjaszewski

doi:10.1021/bm070381+

Synthesis and biodegradation of nanogels as delivery carriers for carbohydrate drugs

Jung Kwon Oh, Daniel J. Siegwart, Krzysztof Matyjaszewski

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151 Scopus citations

Abstract

Biodegradable nanogels loaded with rhodamine B isothiocyanate - dextran (RITC-Dx) as a model for water-soluble biomacromolecular drugs were prepared using atom-transfer radical polymerization (ATRP) in a cyclohexane inverse miniemulsion in the presence of a disulfide-functionalized dimethacrylate cross linker. UV-vis spectroscopy was used to characterize the extent of incorporation of RITC-Dx into the nanogels. The loading efficiency of RITC-Dx into the nanogels, exceeded 80%. These nanogels were degraded into polymeric sols in a reducing environment to release the encapsulated carbohydrate drugs. The released carbohydrate biomolecules specifically interacted with concanavalin A in water, suggesting that the biodegradable nanogels could be used as carriers to deliver carbohydrate drugs that can be released upon degradation to bind to pathogens based on lectins.

Original language	English (US)
Pages (from-to)	3326-3331
Number of pages	6
Journal	Biomacromolecules
Volume	8
Issue number	11
DOIs	https://doi.org/10.1021/bm070381+
State	Published - Nov 1 2007

ASJC Scopus subject areas

Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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abstract = "Biodegradable nanogels loaded with rhodamine B isothiocyanate - dextran (RITC-Dx) as a model for water-soluble biomacromolecular drugs were prepared using atom-transfer radical polymerization (ATRP) in a cyclohexane inverse miniemulsion in the presence of a disulfide-functionalized dimethacrylate cross linker. UV-vis spectroscopy was used to characterize the extent of incorporation of RITC-Dx into the nanogels. The loading efficiency of RITC-Dx into the nanogels, exceeded 80%. These nanogels were degraded into polymeric sols in a reducing environment to release the encapsulated carbohydrate drugs. The released carbohydrate biomolecules specifically interacted with concanavalin A in water, suggesting that the biodegradable nanogels could be used as carriers to deliver carbohydrate drugs that can be released upon degradation to bind to pathogens based on lectins.",

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AU - Siegwart, Daniel J.

AU - Matyjaszewski, Krzysztof

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AB - Biodegradable nanogels loaded with rhodamine B isothiocyanate - dextran (RITC-Dx) as a model for water-soluble biomacromolecular drugs were prepared using atom-transfer radical polymerization (ATRP) in a cyclohexane inverse miniemulsion in the presence of a disulfide-functionalized dimethacrylate cross linker. UV-vis spectroscopy was used to characterize the extent of incorporation of RITC-Dx into the nanogels. The loading efficiency of RITC-Dx into the nanogels, exceeded 80%. These nanogels were degraded into polymeric sols in a reducing environment to release the encapsulated carbohydrate drugs. The released carbohydrate biomolecules specifically interacted with concanavalin A in water, suggesting that the biodegradable nanogels could be used as carriers to deliver carbohydrate drugs that can be released upon degradation to bind to pathogens based on lectins.

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Synthesis and biodegradation of nanogels as delivery carriers for carbohydrate drugs

Abstract

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