Syndrome of inappropriate antidiuretic hormone secretion induced by amiodarone therapy

M. Kamran Aslam, Charlie Gnaim, Jay Kutnick, Robert C. Kowal, Darren K McGuire

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


We describe a case of amiodarone induced hyponatremia consistent with the syndrome of inappropriate antidiuretic hormone (SIADH) that developed during amiodarone loading, similar to three prior reports. The hyponatremia improved after a lower maintenance dose was initiated. This episode was reported online to the FDA (, and future amiodarone labeling will include SIADH as a potential side, effect (personal communication, Wyeth Medical Science). Clinicians should be aware of this rare but serious complication, especially in light of the neurological effect of profound hyponatremia. Amiodarone induced SIADH may develop during the loading phase, and may respond to dose reduction without termination of drug.

Original languageEnglish (US)
Pages (from-to)831-832
Number of pages2
JournalPACE - Pacing and Clinical Electrophysiology
Issue number6 PART I
StatePublished - Jun 2004


  • Adverse drug effect
  • Amiodarone
  • Hyponatremia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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