Syndet is a novel SNAP-25 related protein expressed in many tissues

Guangyi Wang, Joan W. Witkin, Gianming Hao, Vytas A. Bankaitis, Philipp E. Scherer, Giulia Baldini

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


SNAP-25 is a synaptosomal associated protein localized at the plasma membrane of nerve terminals. SNAP-25 associates with syntaxin 1 and vesicle-associated membrane protein-2 (VAMP-2) and is thought to form a complex essential for neurotransmitter release. We have identified syndet, a novel protein related to the family of SNAP-25 isoforms. Like SNAP-25, syndet has regions with high probability of forming coiled coils, a cysteine rich-domain, and lacks a signal sequence or transmembrane domains. Syndet is tightly bound to membranes, possibly by acylation within the cysteine-rich domain. Syndet is expressed in non-neuronal tissues. In adipocytes, syndet is found at the plasma membrane and in an intracellular compartment. The identification of syndet supports the hypothesis that multiple SNAP-25 related proteins ensure specificity of vesicle fusion at the cell surface.

Original languageEnglish (US)
Pages (from-to)505-513
Number of pages9
JournalJournal of cell science
Issue number4
StatePublished - Feb 1997


  • SNAP-25
  • Syndet
  • t-SNARE

ASJC Scopus subject areas

  • Cell Biology


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