Abstract
Sturge-Weber syndrome is a rare congenital disorder. Seizures, stroke-like episodes, glaucoma, headache, and developmental delay are frequently associated features. An Internet-based questionnaire was designed to assess the frequency of use, effectiveness, and safety of aspirin treatment in Sturge-Weber syndrome. Thirty-four of 98 subjects who completed the survey reported having used aspirin. The mean number of reported stroke-like episodes was reduced from 1.1 to 0.3 per month in the year after starting aspirin (n = 26, p =.014). The median number of seizures was significantly reduced from 3 to 1 episodes per month (n = 21, p =.002). Thirty-nine percent of subjects reported a history of complications (predominantly increased bruising or gum/nose bleeding) while on aspirin; however, none reported discontinuing aspirin because of side effects. Our study showed a significant relative reduction in both self-reported seizure frequency and stroke-like episodes after starting aspirin. It also suggests that low-dose aspirin can be safely used in these patients.
Original language | English (US) |
---|---|
Pages (from-to) | 692-702 |
Number of pages | 11 |
Journal | Journal of child neurology |
Volume | 26 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2011 |
Externally published | Yes |
Keywords
- Sturge-Weber syndrome
- aspirin
- seizures
- stroke-like episodes
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology