Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

Andrew Z. Wang; Vaishali Bagalkot; Christophoros C. Vasilliou; Frank Gu; Frank Alexis; Liangfang Zhang; Mariam Shaikh; Kai Yuet; Michael J. Cima; Robert Langer; Philip W. Kantoff; Neil H. Bander; Sangyong Jon; Omid C. Farokhzad

doi:10.1002/cmdc.200800091

Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

Andrew Z. Wang, Vaishali Bagalkot, Christophoros C. Vasilliou, Frank Gu, Frank Alexis, Liangfang Zhang, Mariam Shaikh, Kai Yuet, Michael J. Cima, Robert Langer, Philip W. Kantoff, Neil H. Bander, Sangyong Jon, Omid C. Farokhzad

Research output: Contribution to journal › Article › peer-review

274 Scopus citations

Abstract

(Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.

Original language	English (US)
Pages (from-to)	1311-1315
Number of pages	5
Journal	ChemMedChem
Volume	3
Issue number	9
DOIs	https://doi.org/10.1002/cmdc.200800091
State	Published - Sep 15 2008
Externally published	Yes

Keywords

Doxorubicin
Nanoparticles
Superparamagnetic
TCL-SPION

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

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10.1002/cmdc.200800091

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Wang, A. Z., Bagalkot, V., Vasilliou, C. C., Gu, F., Alexis, F., Zhang, L., Shaikh, M., Yuet, K., Cima, M. J., Langer, R., Kantoff, P. W., Bander, N. H., Jon, S., & Farokhzad, O. C. (2008). Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy. ChemMedChem, 3(9), 1311-1315. https://doi.org/10.1002/cmdc.200800091

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doi = "10.1002/cmdc.200800091",

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AU - Wang, Andrew Z.

AU - Bagalkot, Vaishali

AU - Vasilliou, Christophoros C.

AU - Gu, Frank

AU - Alexis, Frank

AU - Zhang, Liangfang

AU - Shaikh, Mariam

AU - Yuet, Kai

AU - Cima, Michael J.

AU - Langer, Robert

AU - Kantoff, Philip W.

AU - Bander, Neil H.

AU - Jon, Sangyong

AU - Farokhzad, Omid C.

PY - 2008/9/15

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KW - Nanoparticles

KW - Superparamagnetic

KW - TCL-SPION

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Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

Abstract

Keywords

ASJC Scopus subject areas

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