TY - JOUR
T1 - Superior Prognostic Importance of Perineural Invasion vs. Lymph Node Involvement After Curative Resection of Duodenal Adenocarcinoma
AU - Cecchini, Stefano
AU - Correa-Gallego, Camilo
AU - Desphande, Vikram
AU - Ligorio, Matteo
AU - Dursun, Abdulmetin
AU - Wargo, Jennifer
AU - Castillo, Carlos Fernàndez del
AU - Warshaw, Andrew Louis
AU - Ferrone, Cristina Rosa
PY - 2012/1
Y1 - 2012/1
N2 - Background: Unlike other gastrointestinal tumors, lymph node involvement has not consistently been a negative prognostic factor for survival in patients with duodenal adenocarcinoma. Our aim is to examine prognostic factors in patients who underwent a curative resection of their duodenal adenocarcinoma. Methods: A retrospective review of 169 patients diagnosed with primary duodenal lesions between 1982 and 2010 was performed, of whom 103 were treated with curative intent. Clinico-pathologic factors were evaluated. Results: A potentially curative resection was performed in 103 patients with a median age of 67 years (range, 22-91). Perineural and lympho-vascular invasion were identified in 30 (29. 1%) and 39 patients (37. 9%), respectively. Median follow-up was 26. 5 months. The 5-year overall survival was 62% vs. 25% for patients with or without nodal metastases (p < 0. 001) and 56% vs. 19% for patients with or without perineural invasion (p < 0. 001), respectively. Lymph node ratio, type of resection, and size of tumor failed to stratify prognosis. By multivariate analysis, perineural invasion was the most powerful independent predictor of survival (HR, 2. 520; CI, 1. 361-4. 664). Conclusions: Perineural invasion is a stronger predictor for recurrence and survival than tumor size, depth of infiltration, lymph node involvement, and type of resection in patients with duodenal adenocarcinoma.
AB - Background: Unlike other gastrointestinal tumors, lymph node involvement has not consistently been a negative prognostic factor for survival in patients with duodenal adenocarcinoma. Our aim is to examine prognostic factors in patients who underwent a curative resection of their duodenal adenocarcinoma. Methods: A retrospective review of 169 patients diagnosed with primary duodenal lesions between 1982 and 2010 was performed, of whom 103 were treated with curative intent. Clinico-pathologic factors were evaluated. Results: A potentially curative resection was performed in 103 patients with a median age of 67 years (range, 22-91). Perineural and lympho-vascular invasion were identified in 30 (29. 1%) and 39 patients (37. 9%), respectively. Median follow-up was 26. 5 months. The 5-year overall survival was 62% vs. 25% for patients with or without nodal metastases (p < 0. 001) and 56% vs. 19% for patients with or without perineural invasion (p < 0. 001), respectively. Lymph node ratio, type of resection, and size of tumor failed to stratify prognosis. By multivariate analysis, perineural invasion was the most powerful independent predictor of survival (HR, 2. 520; CI, 1. 361-4. 664). Conclusions: Perineural invasion is a stronger predictor for recurrence and survival than tumor size, depth of infiltration, lymph node involvement, and type of resection in patients with duodenal adenocarcinoma.
KW - Duodenal adenocarcinoma
KW - Duodenal cancer
KW - Lymph node
KW - Nodal metastases
KW - Perineural invasion
KW - Predictor
KW - Prognosis
KW - Survival
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U2 - 10.1007/s11605-011-1704-6
DO - 10.1007/s11605-011-1704-6
M3 - Article
C2 - 22005894
AN - SCOPUS:84855352060
SN - 1091-255X
VL - 16
SP - 113
EP - 120
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
IS - 1
ER -