Abstract
The search for new therapeutic agents that are effective against cancer has been difficult and expensive. The activity of anticancer candidate agents against human cancer-derived cell lines in immunocompromised mice is an important tool in this search. Because ATP is a naturally occurring small molecule, its radiolabeled form poses many advantages as a potential anticancer therapeutic agent. We previously found that a single, low-dose intravenous injection of [32P] ATP inhibited the growth of xenografted tumors in nude mice for up to several weeks. The current study describes the biodistribution and the results and advantages of multi-dose administration of this potential drug. Future studies should investigate the mechanism involved in the possible use of [32P]ATP as a cytotoxic agent that homes naturally to the tumor microenvironment.
Original language | English (US) |
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Pages (from-to) | 1878-1882 |
Number of pages | 5 |
Journal | Cell Cycle |
Volume | 11 |
Issue number | 10 |
DOIs | |
State | Published - May 15 2012 |
Externally published | Yes |
Keywords
- Mice
- Tumor inhibition
- Xenografts
- [32P]ATP
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology