225Ac-Prostate-Specific Membrane Antigen Therapy for Castration-Resistant Prostate Cancer: A Single-Center Experience

Yasemin Sanli, Serkan Kuyumcu, Duygu Has Simsek, Fikret Büyükkaya, Caner Civan, Emine Goknur Isik, Zeynep Gozde Ozkan, Mert Basaran, Oner Sanli

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Purpose Prostate-specific membrane antigen (PSMA)-targeted therapies are among the current promising treatments. We present our preliminary results on the use of 225Ac-PSMA therapy in patients with metastatic castration-resistant prostate cancer as a single center. Methods: Twelve advanced stage metastatic castration-resistant prostate cancer patients who received 225Ac-PSMA therapy were recruited in this retrospective study. Patients were treated with 225Ac-PSMA therapy every 8 weeks, and prostate-specific antigen (PSA) response was analyzed. Meanwhile, overall survival (OS) and progression-free survival (PFS) were estimated. Hematological and nonhematological adverse effects were recorded before and at 8 weeks after the last treatment cycle. Results: In total, 25 cycles of 225Ac-PSMA were administered to 12 patients. The pretreatment median PSA level was 129 ng/mL. After the first cycle of therapy, any PSA response was observed in 9 of 12 patients, whereas 6 of them had biochemical response of >50%. Four of 12 patients reached the best PSA response after the first treatment cycle, whereas 3 patients after the second and 2 patients after the third cycle. The median PFS and OS were 4 and 10 months, respectively. For patients with any PSA response after the first cycle, OS was found to be higher despite without any statistical significance (10 vs 4 months; P = 0.301) when compared with the nonresponsive group. No significant difference was encountered in terms of adverse effect in the pretreatment and posttreatment era. Conclusions: Our preliminary results are encouraging, especially patients who had PSA response after the first cycle of 225Ac-PSMA therapy.

Original languageEnglish (US)
Pages (from-to)943-951
Number of pages9
JournalClinical nuclear medicine
Issue number12
StatePublished - Dec 1 2021
Externally publishedYes


  • Ac-PSMA
  • castration-resistant prostate cancer
  • radioligand therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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