Suffering in silence: The tolerance of DNA damage

Research output: Contribution to journalReview articlepeer-review

211 Scopus citations


When cells that are actively replicating DNA encounter sites of base damage or strand breaks, replication might stall or arrest. In this situation, cells rely on DNA-damage-tolerance mechanisms to bypass the damage effectively. One of these mechanisms, known as translesion DNA synthesis, is supported by specialized DNA polymerases that are able to catalyse nucleotide incorporation opposite lesions that cannot be negotiated by high-fidelity replicative polymerases. A second category of tolerance mechanism involves alternative replication strategies that obviate the need to replicate directly across sites of template-strand damage.

Original languageEnglish (US)
Pages (from-to)943-953
Number of pages11
JournalNature Reviews Molecular Cell Biology
Issue number12
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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