Successful use of rituximab in granulomatosis with polyangiitis with aortic inflammation

Lucas Pineda Bernal, Nicole Bitencourt, Kiran Batra, Elizabeth B Solow

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Large-vessel inflammation, although rare, has been increasingly recognised as a complication of granulomatosis with polyangiitis (GPA) in recent years. The presentation is highly variable, ranging from an incidental finding to aortic dissection and rupture. Treatment has predominately consisted of a combination of cyclophosphamide and high dose corticosteroids with surgical intervention when indicated. We present the case of a 34-year-old male diagnosed with GPA after presenting with sinus and eye inflammation and the ensuing investigation revealed large vessel involvement that remarkably improved after 6 months of treatment with the combination of rituximab infusions, methotrexate and corticosteroids.

Original languageEnglish (US)
Pages (from-to)144-147
Number of pages4
JournalClinical and experimental rheumatology
Issue number2
StatePublished - Mar 1 2019

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology


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