Abstract
Minimal change nephrotic syndrome (MCNS) usually is considered to have a good renal prognosis, but the frequency of relapses is a therapeutic challenge to physicians. The treatment of patients with multiple relapses remains a matter of controversy, because few controlled studies are available. We report the case of a 25-year-old man who experienced relapses of MCNS. Single-dose rituximab therapy (total dose 500 mg) was given during the fourth relapse. Complete remission occurred 10 days later, when no CD19/20-positive B cells were detected in the blood. This the first report of efficacy of single-dose rituximab therapy to treat multi-relapsing MCNS in an adult patient.
Original language | English (US) |
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Pages (from-to) | 69-72 |
Number of pages | 4 |
Journal | Clinical Nephrology |
Volume | 72 |
Issue number | 1 |
State | Published - Oct 26 2009 |
Keywords
- Minimal change nephritic syndrome
- Relapse
- Remission
- Rituximab
ASJC Scopus subject areas
- Nephrology