TY - JOUR
T1 - Successful Medical Management of Life-threatening Hepatic Hemangioma in Neonates
AU - Lekwuttikarn, Ramrada
AU - Josephs, Shellie
AU - Teng, Joyce M.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Hepatic hemangioma (HH) is a common asymptomatic, self-limiting benign vascular tumor of the liver in neonates. Although complicated HHs are rare, they have significant risks of morbidity and mortality, especially during the perinatal period. Because of the high risks of complications from surgical interventions, there is an unmet need for effective medical therapy. We report 2 neonates with life-threatening HH who were evaluated for a liver transplant before being treated successfully with combined medical therapy, which included sirolimus, corticosteroids, and propranolol.
AB - Hepatic hemangioma (HH) is a common asymptomatic, self-limiting benign vascular tumor of the liver in neonates. Although complicated HHs are rare, they have significant risks of morbidity and mortality, especially during the perinatal period. Because of the high risks of complications from surgical interventions, there is an unmet need for effective medical therapy. We report 2 neonates with life-threatening HH who were evaluated for a liver transplant before being treated successfully with combined medical therapy, which included sirolimus, corticosteroids, and propranolol.
UR - http://www.scopus.com/inward/record.url?scp=85072848773&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072848773&partnerID=8YFLogxK
U2 - 10.1542/peds.2019-1339
DO - 10.1542/peds.2019-1339
M3 - Article
C2 - 31511312
AN - SCOPUS:85072848773
SN - 0031-4005
VL - 144
JO - Pediatrics
JF - Pediatrics
IS - 4
M1 - e20191399
ER -