Subversion of cell signaling by pathogens

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


Pathogens exploit several eukaryotic signaling pathways during an infection. They have evolved specific effectors and toxins to hijack host cell machinery for their own benefit. Signaling molecules are preferentially targeted by pathogens because they globally regulate many cellular processes. Both viruses and bacteria manipulate and control pathways that regulate host cell survival and shape, including MAPK signaling, G-protein signaling, signals controlling cytoskeletal dynamics, and innate immune responses.

Original languageEnglish (US)
JournalCold Spring Harbor Perspectives in Biology
Issue number9
StatePublished - Sep 2012

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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