Study of laser ablation in the in vivo rabbit brain with MR thermometry

Lili Chen, Janaka P. Wansapura, Gary Heit, Kim Butts

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Purpose: To investigate the peak temperature and thermal dose (T43) as tissue damage indicators for thermal therapy. Materials and Methods: The proton resonant frequency (PRF) shift thermal coefficient was calibrated on six in vivo rabbit brains during interstitial laser ablation. The peak temperature and T43 were correlated with the lesion boundary observed on T2-weighted spin-echo (SE) MRI at 4 hours post-heating in seven thermal lesions using direct MR measurement and analysis based on a binary discriminate model. Results: The peak temperature and T43 were 48.3 ± 1.7°C and 191 ± 219 minutes, respectively, from the direct MR measurement. The values derived by the binary discriminate analysis were 47.8 ± 2.2°C and 28 ± 41 minutes, respectively. Conclusion: Our results suggest that tissue damage in rabbit brain 4 hours after thermal ablation can be predicted reliably from a threshold temperature of approximately 48°C.

Original languageEnglish (US)
Pages (from-to)147-152
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Issue number2
StatePublished - 2002
Externally publishedYes


  • In vivo rabbit brain
  • Interventional MRI
  • Laser ablation
  • Thermal dose
  • Thermometry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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