Abstract
An efficient and asymmetric synthetic approach towards one of the biologically interesting 4(S)-11-diHDHA derivatives was developed. This process mainly relied on two reactions, one is the copper-catalyzed mild cross-coupling that allows for the efficient construction of a chiral α-alkynyl α-hydroxy motif and another is the synthesis of chiral α-hydroxy α-stannanes that has previously been developed by our group featuring the asymmetric stannylation using the well-established tributyltin hydride/diethyl zinc system from an aldehyde.
Original language | English (US) |
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Pages (from-to) | 1624-1628 |
Number of pages | 5 |
Journal | Organic and Biomolecular Chemistry |
Volume | 13 |
Issue number | 6 |
DOIs | |
State | Published - Feb 14 2015 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry