Structure elucidation of nigricanoside A through enantioselective total synthesis

Jie Chen, Panduka Koswatta, J. Robb DeBergh, Peng Fu, Ende Pan, John B. MacMillan, Joseph M. Ready

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Nigricanoside A was isolated from green alga, and its dimethyl ester was found to display potent cytotoxicity. Its scarcity prevented a full structure elucidation, leaving total synthesis as the only means to determine its relative and absolute stereochemistry and to explore its biological activity. Here we assign the stereochemistry of the natural product through enantioselective total synthesis and provide initial studies of its cytotoxicity.

Original languageEnglish (US)
Pages (from-to)2932-2937
Number of pages6
JournalChemical Science
Issue number5
StatePublished - May 1 2015

ASJC Scopus subject areas

  • Chemistry(all)


Dive into the research topics of 'Structure elucidation of nigricanoside A through enantioselective total synthesis'. Together they form a unique fingerprint.

Cite this