@inproceedings{82b18b9662b544ec9c205e5b53480585,
title = "Structural differences between proteins with similar sequences",
abstract = "Similarity between protein sequences is usually predictive of similarity in structures. However, in some rare cases protein domains with significant sequence similarity adopt different structures. Here, we carry out a survey of protein domain pairs with high sequence similarity (measured by HHsearch probability) and low structural similarity (measured by Dali Z-score), aiming to identify the reasons for this discordance. Besides methodological problems with either sequences or structures of domains, we find and describe novel examples of homologs with structural changes.",
keywords = "Domain, Evolution, Homolog, SCOP, Superfamily",
author = "Qian Cong and Kim, {Bong Hyun} and Kinch, {Lisa N.} and Grishin, {Nick V.}",
year = "2010",
month = sep,
day = "6",
doi = "10.1109/BIBE.2010.48",
language = "English (US)",
isbn = "9780769540832",
series = "10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010",
pages = "250--256",
booktitle = "10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010",
note = "10th IEEE International Conference on Bioinformatics and Bioengineering, BIBE-2010 ; Conference date: 31-05-2010 Through 03-06-2010",
}