Structural changes underlying compensatory increase of diffusing capacity after left pneumonectomy in adult dogs

C. C W Hsia, F. Fryder-Doffey, V. Stalder-Navarro, R. L. Johnson, R. C. Reynolds, E. R. Weibel

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


To determine if the functional compensation in diffusing capacity of the remaining lung following pneumonectomy is due to structural growth, we performed morphometric analysis of the right lung in three adult foxhounds ≃2 yr after left pneumonectomy (removal of 42% of lung) and compared the results to those in normal adult dogs previously studied by the same techniques. Diffusing capacity was calculated by an established morphometric model and compared to physiologic estimates at peak exercise in the same dogs after pneumonectomy. The major structural changes after left pneumonectomy are hyperinflation of the right lung, alveolar enlargement, and thinning of the alveolar-capillary tissue barrier. These changes confer significant functional compensation for gas exchange by reducing the overall resistance to O2 diffusion. The magnitude of compensation in diffusing capacity estimated either morphometrically or physiologically is similar. In spite of morphometric and physiologic evidence of functional compensation, there is no evidence of significant growth of structural components. After pneumonectomy, morphometric estimates of diffusing capacity are on average 23% higher than physiologic estimates in the same dogs at peak exercise. We conclude that the previously reported large differences between morphometric and physiologic estimates of diffusing capacity reflects the presence of large physiologic reserves available for recruitment.

Original languageEnglish (US)
Pages (from-to)758-764
Number of pages7
JournalJournal of Clinical Investigation
Issue number2
StatePublished - Aug 1993


  • Exercise
  • Lung resection
  • Morphometry
  • Rebreathing
  • Recruitment

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Structural changes underlying compensatory increase of diffusing capacity after left pneumonectomy in adult dogs'. Together they form a unique fingerprint.

Cite this