Abstract
Thymus-leukemia (TL) antigens have been sequentially immunoprecipitated from glycoprotein pools prepared from lysates of biosynthetically labeled ASL-1w leukemia cells with a monoclonal antibody and a standard alloantiserum. Results suggest that on leukemia cells from Tla(a) mice, as previously reported for thymocytes from these mice, all the alloantiserum-defined TL specificities (TL.1, 2, 3, 5, 6) as well as the specificity defined by the monoclonal antibody (TL.m3) are carried by a single molecular species. The degree of structural homology between the 45,000-m.w. heavy chains of TL and H-2 was investigated by the technique of comparative tryptic peptide mapping. Results indicate that TL is more distantly related at the primary structural level to H-2 than H-2 antigens are to one another.
Original language | English (US) |
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Pages (from-to) | 1712-1717 |
Number of pages | 6 |
Journal | Journal of Immunology |
Volume | 128 |
Issue number | 4 |
State | Published - 1982 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology