Strengthening the Evidence: Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini

Michelle M. Gill; Philisiwe Khumalo; Caspian Chouraya; Mthokozisi Kunene; Futhi Dlamini; Heather J. Hoffman; Angela E. Scheuerle; Bonisile Nhlabatsi; Wiseman Mngometulu; Ntombikayise Dlamini-Madlopha; Nompumelelo Mthunzi; Lynne Mofenson

doi:10.1093/ofid/ofad441

Strengthening the Evidence: Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini

Michelle M. Gill, Philisiwe Khumalo, Caspian Chouraya, Mthokozisi Kunene, Futhi Dlamini, Heather J. Hoffman, Angela E. Scheuerle, Bonisile Nhlabatsi, Wiseman Mngometulu, Ntombikayise Dlamini-Madlopha, Nompumelelo Mthunzi, Lynne Mofenson

Research output: Contribution to journal › Article › peer-review

Abstract

Birth defect surveillance in Eswatini in 2020-2021 identified 0.80% defects (197/24 599 live and stillborn infants). Neural tube defect (NTD) prevalence was 0.08%, 0.08%, and 0.15% for 4902 women on dolutegravir preconception, 17 285 HIV-negative women, and 1320 women on efavirenz preconception, respectively, more definitively refuting the dolutegravir preconception NTD safety signal.

Original language	English (US)
Article number	ofad441
Journal	Open Forum Infectious Diseases
Volume	10
Issue number	9
DOIs	https://doi.org/10.1093/ofid/ofad441
State	Published - Sep 1 2023

Keywords

Eswatini
HIV
birth defect
dolutegravir
surveillance

ASJC Scopus subject areas

Oncology
Infectious Diseases

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10.1093/ofid/ofad441

Cite this

Gill, M. M., Khumalo, P., Chouraya, C., Kunene, M., Dlamini, F., Hoffman, H. J., Scheuerle, A. E., Nhlabatsi, B., Mngometulu, W., Dlamini-Madlopha, N., Mthunzi, N., & Mofenson, L. (2023). Strengthening the Evidence: Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini. Open Forum Infectious Diseases, 10(9), Article ofad441. https://doi.org/10.1093/ofid/ofad441

Strengthening the Evidence: Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini. / Gill, Michelle M.; Khumalo, Philisiwe; Chouraya, Caspian et al.
In: Open Forum Infectious Diseases, Vol. 10, No. 9, ofad441, 01.09.2023.

Research output: Contribution to journal › Article › peer-review

Gill, MM, Khumalo, P, Chouraya, C, Kunene, M, Dlamini, F, Hoffman, HJ, Scheuerle, AE, Nhlabatsi, B, Mngometulu, W, Dlamini-Madlopha, N, Mthunzi, N & Mofenson, L 2023, 'Strengthening the Evidence: Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini', Open Forum Infectious Diseases, vol. 10, no. 9, ofad441. https://doi.org/10.1093/ofid/ofad441

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abstract = "Birth defect surveillance in Eswatini in 2020-2021 identified 0.80% defects (197/24 599 live and stillborn infants). Neural tube defect (NTD) prevalence was 0.08%, 0.08%, and 0.15% for 4902 women on dolutegravir preconception, 17 285 HIV-negative women, and 1320 women on efavirenz preconception, respectively, more definitively refuting the dolutegravir preconception NTD safety signal.",

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Strengthening the Evidence: Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini

Abstract

Keywords

ASJC Scopus subject areas

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