Stoichiometry of chromatin proteins

W. T. Garrard, W. R. Pearson, S. K. Wake, James Bonner

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The stoichiometry of rat liver chromatin proteins has been estimated by quantitative disc electrophoresis. There are about 1.3 × 108 histone and 2.4 × 107 nonhistone polypeptide molecules per haploid genome, an average of one such molecule for every 21 and 117 base pairs of DNA, respectively. Nonhistone proteins have been separated into 115 polypeptide size classes. The total number of molecules represented in distinct size classes ranges from 4.2 × 103 (limits of sensitivity) to 1.7 × 106 per haploid genome, with a mean of 2.1 × 105.

Original languageEnglish (US)
Pages (from-to)50-57
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - May 7 1974

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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