STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges

Kun Yang; Zhen Tang; Cong Xing; Nan Yan

doi:10.1016/j.neuron.2023.10.014

STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges

Kun Yang, Zhen Tang, Cong Xing, Nan Yan

Research output: Contribution to journal › Review article › peer-review

Abstract

Stimulator of interferon genes (STING) is an innate immune signaling protein critical to infections, autoimmunity, and cancer. STING signaling is also emerging as an exciting and integral part of many neurological diseases. Here, we discuss recent advances in STING signaling in the brain. We summarize how molecular threats activate STING signaling in the diseased brain and how STING signaling activities in glial and neuronal cells cause neuropathology. We also review human studies of STING neurobiology and consider therapeutic challenges in targeting STING to treat neurological diseases.

Original language	English (US)
Pages (from-to)	539-557
Number of pages	19
Journal	Neuron
Volume	112
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2023.10.014
State	Published - Feb 21 2024

Keywords

A-T
AD
AGS
ALS
Aicardi-Goutières syndrome
Alzheimer's disease
Hungtington's disease, HD
PD
Parkinson's disease
STING
amyotrophic lateral sclerosis
ataxia-telangiectasia
neurodegenerative disease
neuroinflammation
type I interferon

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2023.10.014

Cite this

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title = "STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges",

abstract = "Stimulator of interferon genes (STING) is an innate immune signaling protein critical to infections, autoimmunity, and cancer. STING signaling is also emerging as an exciting and integral part of many neurological diseases. Here, we discuss recent advances in STING signaling in the brain. We summarize how molecular threats activate STING signaling in the diseased brain and how STING signaling activities in glial and neuronal cells cause neuropathology. We also review human studies of STING neurobiology and consider therapeutic challenges in targeting STING to treat neurological diseases.",

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T2 - Molecular threats, signaling activities, and therapeutic challenges

AU - Yang, Kun

AU - Tang, Zhen

AU - Xing, Cong

AU - Yan, Nan

PY - 2024/2/21

Y1 - 2024/2/21

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AB - Stimulator of interferon genes (STING) is an innate immune signaling protein critical to infections, autoimmunity, and cancer. STING signaling is also emerging as an exciting and integral part of many neurological diseases. Here, we discuss recent advances in STING signaling in the brain. We summarize how molecular threats activate STING signaling in the diseased brain and how STING signaling activities in glial and neuronal cells cause neuropathology. We also review human studies of STING neurobiology and consider therapeutic challenges in targeting STING to treat neurological diseases.

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KW - AD

KW - AGS

KW - ALS

KW - Aicardi-Goutières syndrome

KW - Alzheimer's disease

KW - Hungtington's disease, HD

KW - PD

KW - Parkinson's disease

KW - STING

KW - amyotrophic lateral sclerosis

KW - ataxia-telangiectasia

KW - neurodegenerative disease

KW - neuroinflammation

KW - type I interferon

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JO - Neuron

JF - Neuron

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ER -

STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges

Abstract

Keywords

ASJC Scopus subject areas

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