TY - JOUR
T1 - Stimulation of human sperm capacitation by purified lipid transfer protein
AU - Ravnik, S. E.
AU - Albers, J. J.
AU - Muller, C. H.
PY - 1995/5/1
Y1 - 1995/5/1
N2 - Lipid Transfer Protein I is recognized as a key component involved in high density lipoprotein metabolism. We have been studying lipid transfer in relation to sperm capacitation, a complex series of cell surface events required for the acrosome reaction and fertilization. We have previously shown that Lipid Transfer Protein I is present and active in the female reproductive tract. In the present study, we show that purified Lipid Transfer Protein I directly stimulates human sperm capacitation, but not the acrosome reaction, in the absence of other biological effectors. These results provide strong evidence for a novel role for Lipid Transfer Protein I and reveal, for the first time, a potent activator of capacitation, prior to the acrosome reaction. © 1995 Wiley‐Liss, Inc.
AB - Lipid Transfer Protein I is recognized as a key component involved in high density lipoprotein metabolism. We have been studying lipid transfer in relation to sperm capacitation, a complex series of cell surface events required for the acrosome reaction and fertilization. We have previously shown that Lipid Transfer Protein I is present and active in the female reproductive tract. In the present study, we show that purified Lipid Transfer Protein I directly stimulates human sperm capacitation, but not the acrosome reaction, in the absence of other biological effectors. These results provide strong evidence for a novel role for Lipid Transfer Protein I and reveal, for the first time, a potent activator of capacitation, prior to the acrosome reaction. © 1995 Wiley‐Liss, Inc.
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U2 - 10.1002/jez.1402720110
DO - 10.1002/jez.1402720110
M3 - Article
C2 - 7738519
AN - SCOPUS:0029294657
SN - 0022-104X
VL - 272
SP - 78
EP - 83
JO - Journal of Experimental Zoology
JF - Journal of Experimental Zoology
IS - 1
ER -