Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling

Andrew Murley, Justin Yamada, Bradley J. Niles, Alexandre Toulmay, William A. Prinz, Ted Powers, Jodi Nunnari

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Membrane contact sites (MCSs) function to facilitate the formation of membrane domains composed of specialized lipids, proteins, and nucleic acids. In cells, membrane domains regulate membrane dynamics and biochemical and signaling pathways. We and others identified a highly conserved family of sterol transport proteins (Ltc/Lam) localized at diverse MCSs. In this study, we describe data indicating that the yeast family members Ltc1 and Ltc3/4 function at the vacuole and plasma membrane, respectively, to create membrane domains that partition upstream regulators of the TORC1 and TORC2 signaling pathways to coordinate cellular stress responses with sterol homeostasis.

Original languageEnglish (US)
Pages (from-to)2679-2689
Number of pages11
JournalJournal of Cell Biology
Issue number9
StatePublished - Sep 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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