TY - JOUR
T1 - Stereotactic Body Radiation Therapy for Gynecologic Malignancies
T2 - A Case-Based Radiosurgery Society Practice Review
AU - Ladbury, Colton
AU - Sueyoshi, Mark H.
AU - Brovold, Nellie M.
AU - Kumar, Ritesh
AU - Andraos, Therese Y.
AU - Gogineni, Emile
AU - Kim, Minsun
AU - Klopp, Ann
AU - Albuquerque, Kevin
AU - Kunos, Charles
AU - Leung, Eric
AU - Mantz, Constantine
AU - Biswas, Tithi
AU - Beriwal, Sushil
AU - Small, William
AU - Erickson, Beth
AU - Gaffney, David
AU - Lo, Simon S.
AU - Viswanathan, Akila N.
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Purpose: The use of stereotactic body radiation therapy (SBRT) for gynecologic malignancies is controversial. We discuss certain circumstances when highly precise SBRT may be a useful tool to consider in the management of selected patients. Methods and Materials: Case selection included the following scenarios, the first 2 with palliative intent, para-aortic nodal oligorecurrence of ovarian cancer, pelvic sidewall oligorecurrence of cervical cancer, and inoperable endometrial cancer boost after intensity modulated radiation to the pelvis treated with curative intent. Patient characteristics, fractionation, prescription dose, treatment technique, and dose constraints were discussed. Relevant literature to these cases was summarized to provide a framework for treatment of similar patients. Results: Treatment of gynecologic malignancies with SBRT requires many considerations, including treatment intent, optimal patient selection, fractionation selection, tumor localization, and plan optimization. Although other treatment paradigms including conventionally fractionated radiation therapy and brachytherapy remain the standard-of-care for definitive treatment of gynecologic malignancies, SBRT may have a role in palliative cases or those where high doses are not required due to the unacceptable toxicity that may occur with SBRT. Conclusions: A case-based practice review was developed by the Radiosurgery Society to provide a practical guide to the common scenarios noted above affecting patients with gynecologic malignancies.
AB - Purpose: The use of stereotactic body radiation therapy (SBRT) for gynecologic malignancies is controversial. We discuss certain circumstances when highly precise SBRT may be a useful tool to consider in the management of selected patients. Methods and Materials: Case selection included the following scenarios, the first 2 with palliative intent, para-aortic nodal oligorecurrence of ovarian cancer, pelvic sidewall oligorecurrence of cervical cancer, and inoperable endometrial cancer boost after intensity modulated radiation to the pelvis treated with curative intent. Patient characteristics, fractionation, prescription dose, treatment technique, and dose constraints were discussed. Relevant literature to these cases was summarized to provide a framework for treatment of similar patients. Results: Treatment of gynecologic malignancies with SBRT requires many considerations, including treatment intent, optimal patient selection, fractionation selection, tumor localization, and plan optimization. Although other treatment paradigms including conventionally fractionated radiation therapy and brachytherapy remain the standard-of-care for definitive treatment of gynecologic malignancies, SBRT may have a role in palliative cases or those where high doses are not required due to the unacceptable toxicity that may occur with SBRT. Conclusions: A case-based practice review was developed by the Radiosurgery Society to provide a practical guide to the common scenarios noted above affecting patients with gynecologic malignancies.
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U2 - 10.1016/j.prro.2023.09.008
DO - 10.1016/j.prro.2023.09.008
M3 - Review article
C2 - 37875223
AN - SCOPUS:85178271932
SN - 1879-8500
VL - 14
SP - 252
EP - 266
JO - Practical Radiation Oncology
JF - Practical Radiation Oncology
IS - 3
ER -