Stem cells, mature adipocytes, and extracellular matrix: What does each contribute to fat graft survival?

Ali Mojallal, Christo Shipkov, Charlotte Lequeux, Lucas Rifkin, Rod Rohrich, Spencer Brown, Odile Damour

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


For almost 100 years, fat tissue has been used as soft tissue filler for volume restoration. Fat grafting represents today a major tool in both reconstructive and aesthetic surgery. The discovery of adipose-derived stem cells (ASCs) opened new perspectives in basic science, experimental, and clinical plastic surgery. After fat grafting, the overlying skin gains in terms of thickness and quality. The authors have found that fat tissue can be used for two effects - volume restoration and tissue regeneration. Although the survival of adipose tissue has already been documented in different ways, the major drawback is the unpredictable resorption rates. For both clinical applications of the adipose tissue, an important issue to understand these processes and to solve the aforementioned. The authors discuss the role of cells, extracellular matrix, and biological factors in fat grafting which determine volumetric, regenerative, and bioengineering possibilities.

Original languageEnglish (US)
Title of host publicationStem Cells in Aesthetic Procedures
Subtitle of host publicationArt, Science, and Clinical Techniques
PublisherSpringer-Verlag Berlin Heidelberg
Number of pages21
ISBN (Electronic)9783642452079
ISBN (Print)364245206X, 9783642452062
StatePublished - Nov 1 2014

ASJC Scopus subject areas

  • Medicine(all)


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