TY - JOUR
T1 - Stem Cells
T2 - A Renaissance in Human Biology Research
AU - Wu, Jun
AU - Izpisua Belmonte, Juan Carlos
N1 - Funding Information:
We would like to thank Dr. Jose Maria Campistol for his encouragement and discussions on the importance of thinking on the patients while working with Petri dishes, Dr. Pedro Guillen for his continuous encouragement to bring basic biology discoveries to the patient’s bedside, and all members from the J.C.I.B laboratory for their experimental and conceptual contributions, which led to some of the ideas presented in this review. We would like to thank May Schwarz and Peter Schwarz for their critical reading of the manuscript. Work in the laboratory of J.C.I.B. was supported by the G. Harold and Leila Y. Mathers Charitable Foundation, the Leona M. and Harry B. Helmsley Charitable Trust (2012-PG-MED002), the Moxie Foundation, the McKnight Foundation, the Universidad Católica San Antonio de Murcia (UCAM), and Fundacion Dr. Pedro Guillen.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/6/16
Y1 - 2016/6/16
N2 - The understanding of human biology and how it relates to that of other species represents an ancient quest. Limited access to human material, particularly during early development, has restricted researchers to only scratching the surface of this inherently challenging subject. Recent technological innovations, such as single cell "omics" and human stem cell derivation, have now greatly accelerated our ability to gain insights into uniquely human biology. The opportunities afforded to delve molecularly into scarce material and to model human embryogenesis and pathophysiological processes are leading to new insights of human development and are changing our understanding of disease and choice of therapy options.
AB - The understanding of human biology and how it relates to that of other species represents an ancient quest. Limited access to human material, particularly during early development, has restricted researchers to only scratching the surface of this inherently challenging subject. Recent technological innovations, such as single cell "omics" and human stem cell derivation, have now greatly accelerated our ability to gain insights into uniquely human biology. The opportunities afforded to delve molecularly into scarce material and to model human embryogenesis and pathophysiological processes are leading to new insights of human development and are changing our understanding of disease and choice of therapy options.
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U2 - 10.1016/j.cell.2016.05.043
DO - 10.1016/j.cell.2016.05.043
M3 - Review article
C2 - 27315475
AN - SCOPUS:84975282927
SN - 0092-8674
VL - 165
SP - 1572
EP - 1585
JO - Cell
JF - Cell
IS - 7
ER -