Statins - A cure-all for the brain?

Til Menge, Hans Peter Hartung, Olaf Stüve

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations


'Statins' are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors - oral cholesterol-lowering drugs that are used to treat hypercholesterolaemia. It is widely accepted that statins have anti-inflammatory effects that are independent of their ability to lower cholesterol. Animal studies and observational clinical studies have indicated that statins might also be effective in treating certain neurological diseases - in particular, multiple sclerosis, Alzheimer's disease and ischaemic stroke. At present, however, results from ongoing prospective, randomized clinical trials are not available.

Original languageEnglish (US)
Pages (from-to)325-331
Number of pages7
JournalNature Reviews Neuroscience
Issue number4
StatePublished - Apr 2005

ASJC Scopus subject areas

  • General Neuroscience


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