Spotlight on GOT2 in Cancer Metabolism

Samuel A. Kerk; Javier Garcia-Bermudez; Kivanc Birsoy; Mara H. Sherman; Yatrik M. Shah; Costas A. Lyssiotis

doi:10.2147/OTT.S382161

Spotlight on GOT2 in Cancer Metabolism

Samuel A. Kerk, Javier Garcia-Bermudez, Kivanc Birsoy, Mara H. Sherman, Yatrik M. Shah, Costas A. Lyssiotis

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and dysregulated cancer metabolism. Despite this, recent work has emphasized the remarkable plasticity of cancer cells to employ compensatory pathways when GOT2 is inhibited. Here, we review the metabolic roles of GOT2, highlighting findings in both normal and cancer cells. We emphasize how cancer cells repurpose cell intrinsic metabolism and their flexibility when GOT2 is inhibited. We close by using this framework to discuss key considerations for future investigations into cancer metabolism.

Original language	English (US)
Pages (from-to)	695-702
Number of pages	8
Journal	OncoTargets and Therapy
Volume	16
DOIs	https://doi.org/10.2147/OTT.S382161
State	Published - 2023

Keywords

mitochondria
nucleotides
pancreatic cancer
redox
transaminase
tumor microenvironment

ASJC Scopus subject areas

Oncology
Pharmacology (medical)

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10.2147/OTT.S382161

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title = "Spotlight on GOT2 in Cancer Metabolism",

abstract = "GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and dysregulated cancer metabolism. Despite this, recent work has emphasized the remarkable plasticity of cancer cells to employ compensatory pathways when GOT2 is inhibited. Here, we review the metabolic roles of GOT2, highlighting findings in both normal and cancer cells. We emphasize how cancer cells repurpose cell intrinsic metabolism and their flexibility when GOT2 is inhibited. We close by using this framework to discuss key considerations for future investigations into cancer metabolism.",

keywords = "mitochondria, nucleotides, pancreatic cancer, redox, transaminase, tumor microenvironment",

author = "Kerk, {Samuel A.} and Javier Garcia-Bermudez and Kivanc Birsoy and Sherman, {Mara H.} and Shah, {Yatrik M.} and Lyssiotis, {Costas A.}",

note = "Publisher Copyright: {\textcopyright} 2023 Kerk et al.",

year = "2023",

doi = "10.2147/OTT.S382161",

language = "English (US)",

volume = "16",

pages = "695--702",

journal = "OncoTargets and Therapy",

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TY - JOUR

T1 - Spotlight on GOT2 in Cancer Metabolism

AU - Kerk, Samuel A.

AU - Garcia-Bermudez, Javier

AU - Birsoy, Kivanc

AU - Sherman, Mara H.

AU - Shah, Yatrik M.

AU - Lyssiotis, Costas A.

PY - 2023

Y1 - 2023

N2 - GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and dysregulated cancer metabolism. Despite this, recent work has emphasized the remarkable plasticity of cancer cells to employ compensatory pathways when GOT2 is inhibited. Here, we review the metabolic roles of GOT2, highlighting findings in both normal and cancer cells. We emphasize how cancer cells repurpose cell intrinsic metabolism and their flexibility when GOT2 is inhibited. We close by using this framework to discuss key considerations for future investigations into cancer metabolism.

AB - GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and dysregulated cancer metabolism. Despite this, recent work has emphasized the remarkable plasticity of cancer cells to employ compensatory pathways when GOT2 is inhibited. Here, we review the metabolic roles of GOT2, highlighting findings in both normal and cancer cells. We emphasize how cancer cells repurpose cell intrinsic metabolism and their flexibility when GOT2 is inhibited. We close by using this framework to discuss key considerations for future investigations into cancer metabolism.

KW - mitochondria

KW - nucleotides

KW - pancreatic cancer

KW - redox

KW - transaminase

KW - tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=85169820193&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85169820193&partnerID=8YFLogxK

U2 - 10.2147/OTT.S382161

DO - 10.2147/OTT.S382161

M3 - Review article

C2 - 37635751

AN - SCOPUS:85169820193

SN - 1178-6930

VL - 16

SP - 695

EP - 702

JO - OncoTargets and Therapy

JF - OncoTargets and Therapy

ER -

Spotlight on GOT2 in Cancer Metabolism

Abstract

Keywords

ASJC Scopus subject areas

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