Spontaneous recovery profile of rapacuronium during desflurane, sevoflurane, or propofol anesthesia for outpatient laparoscopy

Tian J. Zhou, Margarita Coloma, Paul F. White, Jun Tang, Tom Webb, John E. Forestner, Nancy B. Greilich, Larry L. Duffy

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


We evaluated the spontaneous recovery characteristics of rapacuronium during desflurane-, sevoflurane-, or propofol-based anesthesia in 51 consenting women undergoing laparoscopic tubal ligation procedures. After the induction of the anesthesia with standardized doses of propofol and fentanyl, 1.5 mg/kg IV rapacuronium was administered to facilitate tracheal intubation. Patients were randomized to receive either 1 minimum alveolar anesthetic concentration of desflurane, 1 minimum alveolar concentration of sevoflurane, or 100 μg · kg-1 · min-1 propofol infusion in combination with 66% nitrous oxide in oxygen for maintenance of anesthesia. Neuromuscular blockade was monitored at the wrist by using electromyography. The degree of maximum blockade and the times for first twitch recovery (T1) to 5%, 25%, 50%, 75%, and 90%, as well as the recovery index, were similar in all three anesthetic groups. However, recovery times for the train-of-four ratio to achieve 0.7 and 0.8 were significantly longer with desflurane (44.4 ± 18.9 and 53.5 ± 22.4 min) and sevoflurane (44.8 ± 15.1 and 53.2 ± 15.8 min) compared with propofol (31.8 ± 5.3 and 36.5 ± 6.5 min). Eight patients (16%) required a maintenance dose of 0.5 mg/kg rapacuronium and reversal of rapacuronium residual block occurred in three (6%) patients. We conclude that spontaneous recovery after an intubating dose of 1.5 mg/kg rapacuronium was significantly prolonged by both desflurane and sevoflurane compared with propofol-based anesthesia. Routine monitoring of neuromuscular activity is recommended even when a single bolus dose of rapacuronium is administered during ambulatory anesthesia.

Original languageEnglish (US)
Pages (from-to)596-600
Number of pages5
JournalAnesthesia and analgesia
Issue number3
StatePublished - 2000

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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